Universitas Mercu Buana

Unggul, Bermutu dan Bermanfaat

Theme of Journal : Identity Edition : I ( 31 Maret 2016 )

1.   Journal Identity
Title          : Are rates of pediatric bipolar disorder increasing? Results from a nationwide
register study
Author      : Lars Vedel Kessing, Eleni Vradi and  Per Kragh Andersen
Volume    : 2
Issue         : 10
Pages        : -
Publication : 2014
ISSN        : -
Copyright : Kessing et al.; licensee Springer. 2014
Document URL : http://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-014-0010-0

Studies from the USA suggest that rates of pediatric bipolar disorder have increased since the mid-90s, but no study outside the USA has been published on the rates of pediatric bipolar disorder. Further, it is unclear whether an increase in rates reflects a true increase in the illness or more diagnostic attention. Using nationwide registers of all inpatients and outpatients contacts to all psychiatric hospitals in Denmark, we investigated (1) gender-specific rates of incident pediatric mania/bipolar disorder during a period from 1995 to 2012, (2) whether age and other characteristics for pediatric mania/bipolar disorder changed during the calendar period (1995 to 2003 versus 2004 to 2012), and (3) whether the diagnosis is more often made at first psychiatric contact in recent time compared to earlier according to gender. Totally, 346 patients got a main diagnosis of a manic episode (F30) or bipolar affective disorder (F31) at least once during the study period from 1995 to 2012. For both sexes, annual rates of mania/bipolar disorder two to four doubled during the study period (0.001% before year 2004 to 0.002%–0.004% in 2010). Median age at the index diagnosis was very similar during the two calendar periods (17.2, quartiles, 16.2–18.3 versus 17.4, quartiles, 16.1–18.2) indicating that the diagnosis of mania/bipolar disorder was not made earlier in the recent calendar period. Similarly, there were no differences between early versus late in the study period in the fractions of first contact diagnosis of mania/bipolar disorder diagnoses, the contact number at which patients got the diagnosis or the duration from first psychiatric contact to the diagnosis of mania/bipolar disorder. The rate of diagnosis of mania/bipolar disorder increased from 1995 to 2014, which did not seem to be explained by more diagnostic attention.

2.   Journal Identity
Title            : Evidence-based guidelines for treating bipolar disorder: revised second edition—recommendations from the British Association for Psychopharmacology
Author         : GM Goodwin
Volume       : 23
Issue            : 4
Pages           : 346–388
Publication  : 2009
ISSN           : 0269-881110.1177/0269881109102919
Copyright     : The Author(s), 2009.
Document URL : http://www.sagepub.co.uk/journalsPermissions.nav

The British Association for Psychopharmacology guidelines specify the scope and target of treatment for bipolar disorder. The second version, like the first, is based explicitly on the available evidence and presented, like previous Clinical Practice guidelines, as recommendations to aid clinical decision making for practitioners: they may also serve as a source of information for patients and carers. The recommendations are presented together with a more detailed but selective qualitative review of the available evidence. A consensus meeting, involving experts in bipolar disorder and its treatment, reviewed key areas and considered the strength of evidence and clinical implications. The guidelines were drawn up after extensive feedback from participants and interested parties. The strength of supporting evidence was rated. The guidelines cover the diagnosis of bipolar disorder, clinical management, and strategies for the use of medicines in treatment of episodes, relapse prevention and stopping treatment.

3.   Journal Identity
Title          : Lithium for prevention of mood episodes in bipolar disorders: systematic review and meta-analysis
Author      : Emanuel Severus, Matthew J Taylor, Cathrin Sauer, Andrea Pfennig, Philipp Ritter and Michael Bauer
and John R Geddes3
Volume    : 2
Issue         : 15
Pages        : -
Publication : 2014
ISSN        : -
Copyright : Severus et al
Document URL : http://www.journalbipolardisorders.com/content/2/1/15

In a previous meta-analysis of randomized controlled trials comparing lithium with placebo as a long-term treatment in bipolar disorders, we observed a clear preventative effect for manic episodes; however, the effect was equivocal for depressive episodes. Since then, the evidence base has grown further. In this update, we furthermore present the data on efficacy of lithium in comparison to alternative drug treatments. In addition, we analyze the data comparing lithium with placebo and other treatments regarding drop-outs due to reasons other than a mood episode and completion of study (no mood episode and no drop-out to reasons other than a mood episode).

4.    Journal Identity
Title              : Mood dynamics in bipolar disorder
Author          : Paul J Moore, Max A Little, Patrick E McSharry, Guy M Goodwin and John R Geddes
Volume        : 2
Issue             : 11
Pages            : -
Publication   : 2014
ISSN            : -
Copyright     : Moore et al.; licensee Springer. 2014
Document URL : http://www.journalbipolardisorders.com/content/2/1/11

The nature of mood variation in bipolar disorder has been the subject of relatively little research because detailed time series data has been difficult to obtain until recently. However some papers have addressed the subject and claimed the presence of deterministic chaos and of stochastic nonlinear dynamics. This study uses mood data collected from eight outpatients using a telemonitoring system. The nature of mood dynamics in bipolar disorder is investigated using surrogate data techniques and nonlinear forecasting. For the surrogate data analysis, forecast error and time reversal asymmetry statistics are used. The original time series cannot be distinguished from their linear surrogates when using nonlinear test statistics, nor is there an improvement in forecast error for nonlinear over linear forecasting methods. Nonlinear sample forecasting methods have no advantage over linear methods in out-of-sample forecasting for time series sampled on a weekly basis. These results can mean that either the original series have linear dynamics, the test statistics for distinguishing linear from nonlinear behaviour do not have the power to detect the kind of nonlinearity present, or the process is nonlinear but the sampling is inadequate to represent the dynamics. We suggest that further studies should apply similar techniques to more frequently sampled data.

5.    Journal Identity
Title            : Mood regulation in bipolar disorders viewed through the pendulum dynamics concept
Author        : Elias Koutsoukos and Elias Angelopoulos
Volume       : 2
Issue           : 9
Pages          : -
Publication : 2014
ISSN          : -
Copyright   : Koutsoukos and Angelopoulos; licensee Springer. 2014
Document URL : http://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-014-0009-6


Bipolar disorders have been characterized by powerful fluctuations of energy, mood, and thinking patterns. Mood episodes (manic or depressive) could be considered as deviations of a psycho-physiological index above or below a conventionally defined value called ‘normothymia’. In the present study, we analyzed the feedback techniques used to suppress the oscillatory activity exhibited on an inverted pendulum device. Subsequently, we examine the degree that this multimodal feedback design could be considered on a hypothetical pendulum where the mood plays the role of the suspended mass, and the force balance compensation circuitry is substituted by drug-specific therapeutic interventions. The study does not concern a model of bipolar illness that could simulate numerically various phases of mood episodes but focuses on the functional similarities regarding the correction treatments applied on the two different oscillating systems giving a potential perspective of how techniques of feedback control may enhance the conceptualization of the treatment schemes followed in recent guidelines for biological treatment of bipolar disorders. Our theoretical consideration, along with observations on clinical level, gives support to the concept that the compensation of the mood oscillations should be adaptive with selective therapeutic interventions that compensate the excited system in different time scales.
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